was incorporated in 2004 and is headquartered in Menlo Park, California. and changed its name to Meta Platforms, Inc. The company was formerly known as Facebook, Inc. The Reality Labs segment provides augmented and virtual reality related products comprising consumer hardware, software, and content that help people feel connected, anytime, and anywhere. Analysts predict Meta Platforms earnings will contract by 10 in 2022 to 12.49 per share, given some of the abovementioned challenges. The company’s stock jumped as much as 20 in off-hours trading after the social-media giant said its costs were set to decline and its global users had increased. The Family of Apps segment offers Facebook, which enables people to share, discuss, discover, and connect with interests Instagram, a community for sharing photos, videos, and private messages, as well as feed, stories, reels, video, live, and shops Messenger, a messaging application for people to connect with friends, family, communities, and businesses across platforms and devices through text, audio, and video calls and WhatsApp, a messaging application that is used by people and businesses to communicate and transact privately. ![]() But it dropped out of that elite group amid concerns about its slowing growth, competitive headwinds, and its commitment to VR devices. ![]() ![]() It operates in two segments, Family of Apps and Reality Labs. Meta became a trillion-dollar stock in 2021. engages in the development of products that enable people to connect and share with friends and family through mobile devices, personal computers, virtual reality headsets, and wearables worldwide.
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![]() The FDA approval for the 9LA regimen is for any PD-L1 type, positive or negative, in non–small cell lung cancer. The duration of response was better for those who responded to treatment, and progression-free survival was better for the 9LA regimen compared with the chemotherapy.įor 9LA, the primary end point was overall survival compared with chemotherapy for all PD-L1 types. It was superior to chemotherapy, and it was superior for overall survival, progression-free survival, and overall response rate. In this trial, the 9LA regimen was positive. To prevent early progression, avoid long-duration toxicity from chemotherapy, then also provide the double immunotherapy for a chance for a higher number of immune responses that will give us a really long duration of benefit, a long-term benefit of 3, 4, and 5 years. That’s particularly a concern in patients who have a high tumor volume or are symptomatic from their cancer, so this regimen gave only 2 cycles of chemotherapy. The reason for the 2 cycles of chemotherapy is that with immunotherapy, sometimes we will see early progression. The experimental arm was nivolumab and low-dose ipilimumab regimen from CheckMate 227 plus 2 cycles of chemotherapy. CheckMate 9LA was a randomized phase 3 trial for all-histology lung cancer, and the control arm was standard histology-based chemotherapy. While CheckMate 227 was a long time coming and it took awhile to have approval for nivolumab and ipilimumab on the CheckMate 227 regimen, 9LA came on us all of a sudden. Ready, MD: I’m going to talk about CheckMate 9LA. Some propose that may be countering hyperprogression, but in any case we see the favorable early benefit from adding chemotherapy in that long-term tail with a dual-checkpoint blockade. We don’t see that crossing of the early curves, just 2 cycles of chemotherapy preventing benefit. ![]() When we look at those Kaplan-Meier curves for PFS, and we don’t see that initial drop. We also saw the PFS benefit, 6.7 months with nivo-ipi –chemotherapy versus 5 months with chemotherapy alone with a hazard ratio of 0.68. One-year survival rates across PD-L1 subsets were 60% to 70%. In the PD-L1–high group, 0.66, which is remarkably similar across. If we look at the PD-L1–negative group, the survival hazard ratio was 0.62. The control arms didn’t necessarily underperform. In both squamous and nonsquamous histologies, really across PD-L1 subsets, the addition of nivo-ipi to 2 cycles of chemotherapy provided a clear benefit over chemotherapy alone. In the squamous, 14.5 months versus 9.1, hazard ratio of 0.62. Broken down by histology in the nonsquamous group, we saw 17-month OS versus 11.9, hazard ratio of 0.69. The 1-year survival rate was 63% compared with 47% with chemotherapy. Overall survival was 15.6 months versus 10.9 months with a hazard ratio of 0.66. Compared with chemotherapy alone, the chemotherapy–nivo-ipi approach did provide a survival benefit. Here it was about 40% PD-L1 negative, so you just want to keep those populations in mind when we look at absolute numbers. ![]() If you look at the PD-L1 breakdown, we would typically expect about a third negative, a third positive low, and a third positive high. About 30% were squamous, a little different from studies like KEYNOTE-024, where it was closer to 20%. Now, it’s important to look at the patient characteristics. When we look at the outcome from this phase 3 registrational trial, over 700 patients randomized, there was a survival benefit. Then, toward the cycles beyond the second round, to lean more on that dual-checkpoint blockade for durable benefit and for more meaningful duration of response. The rationale and strategy is to provide a means to get that initial rapid cytotoxic control, to avoid that initial drop in PFS to provide that benefit for patients with aggressive disease or high burden of disease and facilitate an initial response. The unique wrinkle here is that chemotherapy was given only with the first 2 cycles, not the first 4, and there was no indefinite maintenance chemotherapy. This is a combination of platinum doublet chemotherapy, histology specific, combined with dual-checkpoint blockade using the PD-1 inhibitor nivolumab and the CTLA4 inhibitor ipilimumab. This was the first time in my knowledge that we had approval of the drug before we see any of the data. Stephen Liu, MD: The CheckMate 9LA regimen is the most recent regimen that was added to our treatment arsenal. ![]() At the end of each short round, players are rewarded based on individual and team performance with in-game currency to spend on other weapons or utility in subsequent rounds. Two opposing teams, the Terrorists and the Counter-Terrorists, compete in game modes to repeatedly complete objectives, such as securing a location to plant or defuse a bomb and rescuing or capturing hostages. Global Offensive, like prior games in the Counter-Strike series, is an objective-based, multiplayer first-person shooter. Teams compete in professional leagues and tournaments, with the game often cited as being among the best in esports.Ī major update bringing the game to the Source 2 engine, titled Counter-Strike 2, was announced on Maand is slated to release in summer 2023, with limited test access being made to select players. The game has an active esports scene, continuing the history of international competitive play from previous games in the series. In December 2018, Valve transitioned the game to a free-to-play model, focusing on revenue from cosmetic items. Since its release, it has drawn in an estimated 11 million players per month and remains one of the most played games on Valve's Steam platform. ![]() Global Offensive received positive reviews from critics on release, who praised the game for its gameplay and faithfulness to the Counter-Strike series, though it was criticized for some early features and the differences between the console and PC versions. A battle-royale game-mode, "Danger Zone", was introduced in late 2018. The game also has matchmaking support that allows players to play on dedicated Valve servers, in addition to community-hosted servers with custom maps and game modes. There are nine official game modes, all of which have distinct characteristics specific to that mode. The most common game modes involve the Terrorists planting a bomb while Counter-Terrorists attempt to stop them, or Counter-Terrorists attempting to rescue hostages that the Terrorists have captured. The game pits two teams, Terrorists and Counter-Terrorists, against each other in different objective-based game modes. Valve continues to regularly update the game, both with smaller balancing patches and larger content additions. Developed for over two years, Global Offensive was released for OS X, PlayStation 3, Windows, and Xbox 360 in August 2012, and for Linux in 2014. It is the fourth game in the Counter-Strike series. Counter-Strike: Global Offensive ( CS:GO) is a 2012 multiplayer tactical first-person shooter developed by Valve and Hidden Path Entertainment. ![]() The free service will help you find, manage, and notify you of any changes to your monthly subscriptions from Netflix and gym memberships to recurring bills and utilities and cancel unwanted or fraudulent services in a matter of seconds. Have you ever forgotten to cancel a free trial or discovered an unexpected bill? An automated financial app such as takes care of canceling subscriptions, lowering bills, and refunding bank fees. Go through your expenses line by line, and ask yourself whether each is needed, for example, utilities and health insurance over dining out and streaming video services. Once you've reviewed your monthly expenses and know where your money is going, figure out where you're overspending and what can easily be eliminated. Go through all the line items you're responsible for every month. Look carefully at your monthly expenses, including bank and credit card statements as well as old bills and receipts. If you don't know what you're spending your money on each month, it'll be harder to figure out where you should make cuts. Here are some tips and tricks to lower your monthly expenses: ![]() Those bills can be particularly daunting now as many of us are faced with financial challenges in the wake of the coronavirus pandemic. You might have a feeling that you’re overpaying for certain bills but the thought of actually doing anything about is just too overwhelming. The best way to accomplish this is to cut down on our monthly expenses. Yet, one of the biggest challenges is figuring out ways to spend less money. You can always look at your bank statements to spot which streaming service can go, or a service like Trim can investigate unwanted subscriptions and unsubscribe them for you.All of us would love to see more money in our pockets and this can be possible by simply making a few changes in our everyday lifestyle. Like I have a long standing deal with my family where I use my dad's Netflix account, but the 'rents use my Hulu account. Suffice to say, you probably don't need a trillion of them, and can almost definitely password-swap with someone. Netflix, Hulu, Amazon Prime, Disney+, HBO Max-like what even is that last one? Why does HBO have no less than three streaming services. You should call and negotiate for more of that money in your pocket." 2. "Especially because of the pandemic with people driving less, car insurance companies have saved a ton of money on reduced accident claims. "Car insurance is always a monthly budget expense where you can negotiate," says Financial Gym founder and CEO Shannon McLay. Or maybe you're still working out in the real world but long road trips or any semblance of a social life is far in the rearview mirror. Shannon McLay, Shannon McLay is the founder and CEO of Financial Gym, a company with a team of personal finance coaches who help clients take control of their budgets, spending, and saving habits.Įasy ways to reduce monthly expenses 1. ![]() Below, a few suggestions for the benefit of your bank account. But there are also new, simple opportunities to cut back on your day-to-day spendings, particularly if your day-to-day looks different now. ![]() And there might be frighteningly new expenses to pay for during the pandemic, don't get me wrong. The thing is, despite this definitely being tough times with two capital Ts, 34 percent of participants said they've yet to slice the cost of their monthly expenses. One way to feel in control when everything is out of wack? Reduce monthly expenses. But all seriousness aside, this has been a financially dark period for many- mass job layoffs following the first wave and a second still-to-be-negotiated stimulus package make that clear. In fact, a recent Credit Karma survey of 1,043 Americans revealed what our post-pandemic spending habits are, and shocker, nobody's going to concerts or movies any time soon. Pandemic has redefined what's a worthwhile investment for you, me, and probably everyone who isn't a billionaire. ![]() With our experience of more than 18 years, we have the expertise to help you make the right choice and deliver our customers an exceptional service. The owner of the company believes in delivering excellence in installation and repair of screen INS. Our customer care team is amazing and will answer your questions quickly and comprehensively. Our advice will always be sincere and you can rely on it to help you make the best selection. We welcome you to explore the diverse selections that we offer and make the right choice that suits your style and which delivers the right results based on the enclosure that you have erected outside your main house. With our experienced and expert staff, you can get the best screen INS that you require for your home. We also take into account the best material, color and style that may compliment your home. Our team will take into consideration the size of the area that needs to be covered among other considerations. is the best choice for your next room enclosure!ĭo you enjoy outdoor living in pergola, patios and gazebos among others? We understand that outdoor living is one of the many ways that you can use to accent your yard area, adding a special touch to your exterior space and adding elegance while providing a shaded and cool refuge.Īt Meyer Screens Inc., we help you in selecting the best screen in those suits your unique requirements. We accept major credit cards or personal checks.Experience Why Meyers Screens Inc. Serving: Apopka, Belle Isle, Celebration, Clermont, Conway, Davenport, Daytona, Edgewater, Kissimmee, Maitland, Mims, Ocoee, Orlando, Oviedo, Titusville, Windemere, Winter Garden, Winter Park, and Winter Springs. Its made of high quality aluminum, is weather sealed all around and is available in white or bronze. Our screen offers and exit door without having to retract the entire screen. Garage Door Screens – the system uses a vertical and horizontal track system mounted directly inside the existing door, leaving the floor track-free. Available with charcoal insect screen or white solar screen. This roller shade screen is the perfect choice for patio enclosures, gazebos, garage doors and other openings that are up to 10 feet tall and 19 feet wide. ![]() Roller Shade Screens – available in a manual version with a pull chain or motorized with a portable remote control. The sheer pleated screen door can be easily configured in single panel, double panel or multiple panels. This feature makes it wheelchair accessible too. ![]() ![]() The screen moves with a gentle touch and the track installs flat so there’s nothing to trip on or step over. Sheer Screen Pleated Screens - perfect for single, double, French Doors and even openings up to 30 ft. These are available for vertical or horizontal applications. The components are engineered to last with durable powder coating that easy to clean and the screen fabric is tear resistant. Retractable Screens – the screen disappears into protective housing when not in use and the screen cassette protects the screen from dirt, ultra violet light and inclement weather. May Construction’s retractable screens can be used on garages, screen porch areas, gazebos, and on any door or window. May Construction installs Retractable Screens, including Sheer Screen Pleated, Roller Shade, and Garage Door Screens. Georgia is also slightly wider and incorporates serifs with flatter ends. Times New Roman’s axis is less diagonal than Georgia as seen in the lowercase g. The x-height of Georgia is higher than that of Times New Roman, and is larger at the same point size. Mr Eaves XL Sans and XL Modern feature four weights with accompanying italics, small caps and alternate characters. The main point of the typeface is to be legible on low resolution screens vs printing. The Modern Italic is free of tails, and overall the Modern exhibits more repetition of forms, projecting a cleaner look. This family has moved furthest from its roots, yet still contains some of Mrs Eaves’ DNA. Neue June is a unique typeface, with its innovative high x-height, full-bodied and round punctuation. In typography, the space between fonts is called leading (pronounced led-ing, not leed-ing), named after the pieces of lead between lines of type. The font family includes 7 normal and 7 outline styles, making it versatile, and a great option for any branding project. The matching Modern family provides an overall less humanistic look, with simpler and more geometric-looking shapes, most noticeably in the squared-off terminals and symmetric lower case counters. MADE TOMMY is a sans serif that is classic and casual. Like the Sans, the XL Sans version relates most directly to the serif version, noticeably in the roman lower case letters a, e, and g, as well as in subtle details such as the angled lead-in strokes, the counter forms of the b, d, p, and q, and the flared leg of the capital R, and the tail of the Q. Its vertically-cut stroke endings and compact proportions make. The larger x-height also maintains superior readability at smaller point sizes. LL Moderne is a humanist sans serif with dynamic curves, open counters and a high x-height. ![]() Mr Eaves XL allows for a wide variety of uses and is perfectly suitable for lengthy text settings. The ratio between the x-height and the ascent or cap height often serves to characterize typefaces. ![]() ![]() Mr Eaves XL Sans features a larger x-height than Mr Eaves Sans with shorter ascenders and descenders and overall tighter spacing. The height of the ascender can have a dramatic effect on the readability and appearance of a font. Classic humanist typefaces have a very small x-height. This height is different in relation to the cap height, that is of the. This XL version of Mr Eaves completes the fourth quadrant of the Mrs Eaves and Mr Eaves families. The x-height is the height of lowercase letters in a typeface, such as m, a or z. ![]() Beautiful Set! Please See Scans!! A must have for any serious Wolverine and/or Havok collector / enthusiast. Overall, if you haven’t read Havok/Wolverine: Meltdown, and you like the way X-Men comics used to be, back before every event was an extinction-level threat against mutantkind, you really should. Collectible Entertainment note: Trade Paperbacks 1,2,3,4 are in Very Fine + condition. Epic Comics / Marvel Comics - Trade Paperbacks are bagged & boarded and will be carefully / securely packaged then shipped via USPS Priority Mail to ensure that it arrives to you perfectly and quickly. Rating Havok & Wolverine: Meltdown Average 0.00 /5 - out of 0 total votes. Status Completed Genres Superhero - Marvel. Issue 4: Scarlett finds Havok, devastated he had to kill Wolverine. Comic list Havok & Wolverine: Meltdown Havok & Wolverine: Meltdown Updated at: 17:54:39 Other Names Havok & Wolverine: Meltdown 1989 Author(s) Walt Simonson. ![]() Inside, hes attacked by his brainwashed teammate, and in self-defense, he uses a full power blast, killing Wolverine, just as Scarlett planned. Trade Paperback Lot contains: Havok & Wolverine: Meltdown (1988 - 1989) Issues #1-4. Arriving in Poland, Havok and Scarlett reach a KGB facility where Havok believes Wolverine is being held. By using them, they would cause another meltdownone that would change the course of history. The powers would have to try again And so when X-Men members Wolverine and Havok were vacationing in Mexico, they were recruited by Soviet agents. And although the destruction caused a slowdown in the reforms, it did not stop them. Simonson story (1988) Meltdown: Part 1 of 4 - Written by Walt and Louise Simonson. Wolverine, a feral warrior with an uncanny healing factor, an unbreakable Adamantium skeleton and razor-sharp claws. Two X-Men Havok, gifted with the ability to project devastating plasma bursts. Fast loading speed, unique reading type: All pages - just need to scroll to read next. Then, in a carefully arranged series of accidents, they managed to cause a meltdown in the nuclear facility at Chernobyl. JCollects Havok & Wolverine: Meltdown 1-4. Read Havok & Wolverine: Meltdown comic online free and high quality. Instead they would do whatever was necessary to halt glasnost. But some in power were not so eager for change. Glasnost was tearing down walls in society, changing down the old ways. Havok and Wolverine head south of the border and get caught up in a caper not even mutant super heroes can survive. ![]() Overusing our search engine with a very large number of searches in a very short amount of time.Using a badly configured (or badly written) browser add-on for blocking content.Running a "scraper" or "downloader" program that either does not identify itself or uses fake headers to elude detection.Using a script or add-on that scans GameFAQs for box and screen images (such as an emulator front-end), while overloading our search engine.There is no official GameFAQs app, and we do not support nor have any contact with the makers of these unofficial apps. Continued use of these apps may cause your IP to be blocked indefinitely. This triggers our anti-spambot measures, which are designed to stop automated systems from flooding the site with traffic. Some unofficial phone apps appear to be using GameFAQs as a back-end, but they do not behave like a real web browser does. ![]() Using GameFAQs regularly with these browsers can cause temporary and even permanent IP blocks due to these additional requests. If you are using the Brave browser, or have installed the Ghostery add-on, these programs send extra traffic to our servers for every page on the site that you browse, then send that data back to a third party, essentially spying on your browsing habits.We strongly recommend you stop using this browser until this problem is corrected. The latest version of the Opera browser sends multiple invalid requests to our servers for every page you visit.The most common causes of this issue are: Your IP address has been temporarily blocked due to a large number of HTTP requests. This chapter presents ideas for displaying and presenting origami animals, making them a delightful addition to home decor or gifts. Once the origami animals are complete, it’s time to showcase them. We also delve into the artistic possibilities by discussing the use of different colors and patterns when selecting origami paper. Moreover, we explore ways to embellish origami animals with additional details, encouraging readers to personalize their creations. Origami can sometimes present challenges, but fear not! In this section, we offer practical tips and troubleshooting advice to overcome common obstacles encountered during folding. ![]() Finally, for those seeking a challenge, we showcase advanced origami animal designs like the majestic lion, horse, and delicate butterfly. As readers gain confidence, they can progress to intermediate-level designs like the graceful elephant, bird, and fish. We begin with simple designs perfect for beginners, such as the adorable origami frog, cat, and dog. This chapter provides a collection of origami animal designs suitable for various skill levels. Additionally, we discuss the different types of origami paper available and recommend tools that can enhance the folding experience. This section introduces readers to fundamental origami techniques and terminology.
Name = "example" description = "Test app" labels = generated by Terraform" name = random_password.bot_token. Headers is a list of headers to inject when passing the request over to the application. Redirect defines a list of hosts which will be rewritten to the public address of the application if they occur in the "Location" header. Rewrite is a list of rewriting rules to apply to requests and responses. NameĮxternalID is the AWS External ID used when assuming roles in this app.ĭynamicLabels are the app's command labels. Rewrite is a list of rewriting rules to apply to requests and responses.ĪWS contains additional options for AWS applications. Annotate the Kubernetes service account with the IAM role ARN and the IAM. PublicAddr is the public address the application is accessible at. The kubectl command line tool is installed on your device or AWS CloudShell. InsecureSkipVerify disables app's TLS certificate verification. The field should be called "namespace" when it returns in Teleport 2.4.ĪWS contains additional options for AWS applications.Ĭloud identifies the cloud instance the app represents.ĭynamicLabels are the app's command labels. NameĮxpires is a global expiry time header can be set on any resource in the system. A value of 'true' for this annotation declares that the object is only consumed by client-side tooling and should not be submitted to the API server. If more than one are provided, they will be tried in the order above until one succeeds.Īddr = "localhost:3025" cert_path = "tf.crt" key_path = "tf.key" root_ca_path = "tf.ca" This annotation is used in manifests to mark an object as local configuration that should not be submitted to the Kubernetes API. ![]() The retry_* values are used to retry the API calls to Teleport when the cache is stale. ![]() profile_name, profile_dir (both can be empty) and addr to connect using current profile from ~/.tsh. ![]()
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